CP violation and mass hierarchy at medium baselines in the large theta(13) era

The large value of theta(13) recently measured by rector and accelerator experiments opens unprecedented opportunities for precision oscillation physics. In this paper, we reconsider the physics reach of medium baseline superbeams. For theta(13) ~ 9 degree we show that facilities at medium baselines -- i.e. L ~ O(1000 km) -- remain optimal for the study of CP violation in the leptonic sector, although their ultimate precision strongly depends on experimental systematics. This is demonstrated in particular for facilities of practical interest in Europe: a CERN to Gran Sasso and CERN to Phyasalmi nu_mu beam based on the present SPS and on new high power 50 GeV proton driver. Due to the large value of theta(13), spectral information can be employed at medium baselines to resolve the sign ambiguity and determine the neutrino mass hierarchy. However, longer baselines, where matter effects dominate the nu_mu->nu_e transition, can achieve much stronger sensitivity to sign(Delta m^2) even at moderate exposures.Comment: 14 pages, 14 figures, version to appear in EPJ

Rainstorms able to induce flash floods in a Mediterranean-climate region (Calabria, southern Italy)

Abstract. Heavy rainstorms often induce flash flooding, one of the natural disasters most responsible for damage to man-made infrastructures and loss of lives, also adversely affecting the opportunities for socio-economic development of Mediterranean countries. The frequently dramatic damage of flash floods are often detected, with sufficient accuracy, by post-event surveys, but rainfall causing them are still only roughly characterized. With the aim of improving the understanding of the temporal structure and spatial distribution of heavy rainstorms in the Mediterranean context, a statistical analysis was carried out in Calabria (southern Italy) concerning rainstorms that mainly induced flash floods, but also shallow landslides and debris flows. Thus, a method is proposed – based on the overcoming of heuristically predetermined threshold values of cumulated rainfall, maximum intensity, and kinetic energy of the rainfall event – to select and characterize the rainstorms able to induce flash floods in the Mediterranean-climate countries. Therefore, the obtained (heavy) rainstorms were automatically classified and studied according to their structure in time, localization, and extension. Rainfall-runoff watershed models can consequently benefit from the enhanced identification of design storms, with a realistic time structure integrated with the results of the spatial analysis. A survey of flash flood events recorded in the last decades provides a preliminary validation of the method proposed to identify the heavy rainstorms and synthetically describe their characteristics. The notable size of the employed sample, including data with a very detailed resolution in time that relate to several rain gauges well-distributed throughout the region, gives robustness to the obtained results

A novel technique for the measurement of the electron neutrino cross section

Absolute neutrino cross section measurements are presently limited by uncertainties on $\nu$ fluxes. In this paper, we propose a technique that is based on the reconstruction of large angle positrons in the decay tunnel to identify three-body semileptonic $K^+ \rightarrow e^+ \pi^0 \nu_e$ decays. This tagging facility operated in positron counting mode ("event count mode") can be employed to determine the absolute $\nu_e$ flux at the neutrino detector with ${\cal O}(1\%)$ precision. Facilities operated in "event by event tag mode" i.e. tagged neutrino beams that exploit the time coincidence of the positron at source and the $\nu_e$ interaction at the detector, are also discussed.Comment: 23 pages, 7 figures. Version to appear in EPJ

A three solar cell system based on a self-supporting, transparent AlGaAs top solar cell

Development of a three solar cell stack can lead to practical efficiencies greater than 30 percent (1x,AM0). A theoretical efficiency limitation of 43.7 percent at AM0 and one sun is predicted by this model. Including expected losses, a practical system efficiency of 36.8 percent is anticipated. These calculations are based on a 1.93eV/1.43eV/0.89eV energy band gap combination. AlGaAs/GaAs/GaInAsP materials can be used with a six-terminal wiring configuration. The key issues for multijunction solar cells are the top and middle solar cell performance and the sub-bandgap transparency. AstroPower has developed a technique to fabricate AlGaAs solar cells on rugged, self-supporting, transparent AlGaAs substrates. Top solar cell efficiencies greater than 11 percent AM0 have been achieved. State-of-the-art GaAs or InP devices will be used for the middle solar cell. GaInAsP will be used to fabricate the bottom solar cell. This material is lattice-matched to InP and offers a wide range of bandgaps for optimization of the three solar cell stack. Liquid phase epitaxy is being used to grow the quaternary material. Initial solar cells have shown open-circuit voltages of 462 mV for a bandgap of 0.92eV. Design rules for the multijunction three solar cell stack are discussed. The progress in the development of the self-supporting AlGaAs top solar cell and the GaInAsP bottom solar cell is presented

NEISSERIA MENINGITIDIS SEROGROUP B CARRIAGE BY ADOLESCENTS AND YOUNG ADULTS LIVING IN MILAN, ITALY: GENETIC CHARACTERISTICS AND POTENTIAL CORRELATION WITH PRESENTLY AVAILABLE MENB VACCINE.

Recently, two vaccines against meningococcal serogroup B have been developed. They are prepared according to the reverse vaccinology approach and contain four and two cross-reactive surface proteins. These vaccines, manufactured by GSK and Pfizer, are Bexsero (4CMenB) and Trumenba (MenB-fHbp) respectively. In Italy Bexsero vaccine has been included in the official vaccination schedule and is recommended for infants, adolescents and adults, whereas Trumenba is recommended for adolescents. In order to collect information about the present carriage of Neisseria meningitidis serogroup B in Italian adolescents and to evaluate the potential protection offered by the presently available MenB vaccines, 2,560 otherwise healthy, high school students aged 14-21 years (907 males, 35.4%, median age 16.2 years) were enrolled in Milan, Italy. A swab to collect posterior pharynx secretions was collected from each subject and meningococcal identification, serogrouping, multilocus sequence typing analysis, sequence alignments and phylogenetic analysis were performed. A total of 135 (5.3%) adolescents were meningococcal carriers. Strains belonging to serogroup B were the most common (n = 58; 43%), followed by MenY (n = 32; 23.7%), MenC (n = 7; 5.2%), MenW135 (n = 6; 4.4%) and MenX (n = 5; 3.7%). The remaining bacteria were not capsulated. The identified MenB strains belonged to eleven clonal complexes (CCs): ST-162 CC (n = 12; 20.7%), ST-865 CC (n = 12; 20.7%), ST-41/44/Lin.3 CC (n = 11; 19.0%), ST-35 CC (n = 6; 10.3%), ST-32/ET-5 CC (n = 4; 6.9%), ST-269 CC (n = 3; 5.2%), ST-213 CC (n = 2; 3.4%), ST-198 CC (n = 1; 1.7%), ST-461 CC (n = 1; 1.7%), ST-549 CC (n = 1; 1.7%), and ST-750 CC (n = 1; 1.7%). The analysis of proteins included in two vaccines show that, regarding fHbp gene, all strains except 3 harbored fHbp alleles represented by a total of 31 sub-variants: 18 in variant 1 (v.1 n=25; 45.4%), 8 in variant 2 (v.2 n=25; 45.4%) and 5 in variant 3 (v.3, n=5; 9.1%). The data concerning the percentage of amino acid identity shows that for the detected fHbp sub-variants 1 the identity towards Bexsero varies from 90.9% to 99.2% (median: 96.1%) instead against Trumenba varies from 87.7% to 93.1% (median: 89.2%). The identity regarding detected sub-variant 3 towards the MenB fHbp varies from 93.7% to 100% (median 97.6%). The gene for NHBA protein was found in all strains except for 6 (10.3%) and 21 sub-variants were identified. The sub-variants had an amino acid identity towards the protein included in the Bexsero varying from 71.3% to 99.8% (median: 76%). PorA gene were identified in 53 out of the 58 (91.4%) studied MenB strains and 22 porA sub-types were identified. The amino acid identity between the studied porA proteins and those were included in the Bexsero vaccine was not less than 88.1% (median: 91.8%). The gene for NadA proteins was not detected in any of the 58 studied strains, as expected in carried strains. In conclusion, in adolescent living in Milan, Neisseria meningitidis serogroup B was the most commonly carried followed by serogroup Y. The MenB vaccines presently licensed induce the production of antibodies effective against the greatest part of the identified MenB strains. Monitoring carriage remains essential to evaluate MenB circulation and long-term studies will be useful to evaluate the effects on the carriage and the final efficacy of both new MenB vaccines

3D Porous Architecture of Stacks of β-TCP Granules Compared with That of Trabecular Bone: A microCT, Vector Analysis, and Compression Study

The 3D arrangement of porous granular biomaterials usable to fill bone defects has received little study. Granular biomaterials occupy 3D space when packed together in a manner that creates a porosity suitable for the invasion of vascular and bone cells. Granules of beta-tricalcium phosphate (β-TCP) were prepared with either 12.5 or 25 g of β-TCP powder in the same volume of slurry. When the granules were placed in a test tube, this produced 3D stacks with a high (HP) or low porosity (LP), respectively. Stacks of granules mimic the filling of a bone defect by a surgeon. The aim of this study was to compare the porosity of stacks of β-TCP granules with that of cores of trabecular bone. Biomechanical compression tests were done on the granules stacks. Bone cylinders were prepared from calf tibia plateau, constituted high-density (HD) blocks. Low-density (LD) blocks were harvested from aged cadaver tibias. Microcomputed tomography was used on the β-TCP granule stacks and the trabecular bone cores to determine porosity and specific surface. A vector-projection algorithm was used to image porosity employing a frontal plane image, which was constructed line by line from all images of a microCT stack. Stacks of HP granules had porosity (75.3 ± 0.4%) and fractal lacunarity (0.043 ± 0.007) intermediate between that of HD (respectively 69.1 ± 6.4%, p < 0.05 and 0.087 ± 0.045, p < 0.05) and LD bones (respectively 88.8 ± 1.57% and 0.037 ± 0.014), but exhibited a higher surface density (5.56 ± 0.11 mm(2)/mm(3) vs. 2.06 ± 0.26 for LD, p < 0.05). LP granular arrangements created large pores coexisting with dense areas of material. Frontal plane analysis evidenced a more regular arrangement of β-TCP granules than bone trabecule. Stacks of HP granules represent a scaffold that resembles trabecular bone in its porous microarchitecture

Kinetic description of hadron-hadron collisions

A transport model based on the mean free path approach to describe pp collisions is proposed. We assume that hadrons can be treated as bags of partons similarly to the MIT bag model. When the energy density in the collision is higher than a critical value, the bags break and partons are liberated. The partons expand and can make coalescence to form new hadrons. The results obtained compare very well with available data and some prediction for higher energies collisions are discussed. Based on the model we suggest that a QGP could already be formed in the pp collisions at high energies

Three-dimensional arrangement of β-tricalcium phosphate granules evaluated by microcomputed tomography and fractal analysis.

The macrophysical properties of granular biomaterials used to fill bone defects have rarely been considered. Granules of a given biomaterial occupy three-dimensional (3-D) space when packed together and create a macroporosity suitable for the invasion of vascular and bone cells. Granules of β-tricalcium phosphate were prepared using polyurethane foam technology and increasing the amount of material powder in the slurry (10, 11, 15, 18, 21 and 25g). After sintering, granules of 1000-2000μm were prepared by sieving. They were analyzed morphologically by scanning electron microscopy and placed in polyethylene test tubes to produce 3-D scaffolds. Microcomputed tomography (microCT) was used to image the scaffolds and to determine porosity and fractal dimension in three dimensions. Two-dimensional sections of the microCT models were binarized and used to compute classical morphometric parameters describing porosity (interconnectivity index, strut analysis and star volumes) and fractal dimensions. In addition, two newly important fractal parameters (lacunarity and succolarity) were measured. Compression analysis of the stacks of granules was done. Porosity decreased as the amount of material in the slurry increased but non-linear relationships were observed between microarchitectural parameters describing the pores and porosity. Lacunarity increased in the series of granules but succolarity (reflecting the penetration of a fluid) was maximal in the 15-18g groups and decreased noticeably in the 25g group. The 3-D arrangement of biomaterial granules studied by these new fractal techniques allows the optimal formulation to be derived based on the lowest amount of material, suitable mechanical resistance during crushing and the creation of large interconnected pores